East of I-295, NY 25 intersects the western terminus of NY 25B NY 25 turns southeast onto Braddock Avenue while Hillside Avenue continues east as Route 25B. In Queens Village the route connects with both I-295 and NY 24 at an interchange that serves as NY 24's western end and I-295's southern terminus. This section of NY 25 is undivided but has several lanes in the Jamaica- Hollis area. Three blocks southeast of I-678, NY 25 turns east and is known as Hillside Avenue, a city street that begins at Jamaica Avenue in Richmond Hill near the site of the former LIRR station. Near Jamaica, the road meets I-678 at exit 9, a partial interchange. In Kew Gardens the route is connected to the westbound and eastbound roadways of Union Turnpike and passes over the Jackie Robinson Parkway without access. Outside of Rego Park, NY 25 turns slightly southeast towards Forest Hills and Jamaica.

In Corona, the road intersects the Long Island Expressway (I-495) and the northern terminus of Woodhaven Boulevard. In Elmhurst, the road runs over the eponymous subway line starting at the intersection with Grand Boulevard and Broadway. In Woodside, NY 25 meets I-278 at exit 39. At Thompson Avenue, the route turns to run eastward as the multi-lane divided Queens Boulevard, straddling the Flushing Line's elevated structure eastward to 48th Street, at which point the Flushing Line turns northeast onto Roosevelt Avenue and Queens Boulevard becomes 6 lanes in each direction, with main and service roads. In Long Island City, NY 25 runs southeast beneath the elevated tracks of the IRT Flushing Line. Queens Plaza is based around this section of the road. East of the bridge NY 25 becomes Queens Boulevard at the intersection with NY 25A, in the Long Island City section of the borough of Queens. NY 25 begins near Second Avenue in Manhattan, at the western end of the double-decked Queensboro Bridge spanning the East River and Roosevelt Island. Main articles: Queens Boulevard and Jamaica Avenue They began as two separate routes, one between Laurel and Mattituck and the other in the vicinity of Greenport however, they were effectively merged after a truck route was established between Mattituck and Greenport. Two alternate routings exist bearing the designation NY 25 Truck, both along the North Fork of Long Island. Further east, the highway becomes Main Street in Smithtown, Middle Country Road in central Suffolk, Main Street again in Riverhead, and finally Main Road in eastern Suffolk. Continuing east through Nassau and western Suffolk counties, NY 25 retains the name Jericho Turnpike. At that point, NY 25 turns east onto Jericho Turnpike, which runs along the Queens-Nassau border from Braddock Avenue to 257th Street. Braddock Avenue ends immediately upon crossing over the Cross Island Parkway. In the borough of Queens, it is called Queens Boulevard, Hillside Avenue and finally Braddock Avenue. NY 25 runs along several differently-named roads. It is also one of only two signed New York State routes in Manhattan (the other is NY 9A.) NY 25 is unique among New York State Routes on Long Island, as it is the only one to leave the geographical boundaries of Long Island, albeit minimally it ends at the western terminus of the Queensboro Bridge. NY 25 is carried from Manhattan to Queens by way of the double-decked Queensboro Bridge over the East River. The route extends for just over 105 miles (169 km) from east midtown Manhattan in New York City to the Cross Sound Ferry terminal at Orient Point on the end of Long Island's North Fork. New York State Route 25 ( NY 25) is an east–west state highway in downstate New York in the United States. I-295 / Grand Central Parkway in Hollis Hills (4) Middle Country Road in Suffolk County.(3) Jericho Turnpike on most of Long Island.

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